Is trisomy cause or consequence of murine T cell leukemia development? Studies on Robertsonian translocation mice.
Open Access
- 1 December 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (12) , 6619-6621
- https://doi.org/10.1073/pnas.76.12.6619
Abstract
Trypsin-Giemsa banding studies on T cell leukemias induced in Robertsonian translocation mice by dimethylbenz[a]anthracene and Moloney leukemia virus show a trisomy of chromosome 15 even in cases in which chromosome 15 has undergone centromeric fusion with chromosomes 1, 5, or 6. These results suggest that the duplication of gene(s) located on chromosome 15 is of critical importance for murine T cell leukemia development.This publication has 6 references indexed in Scilit:
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- Cytogenetic mapping of the trisomic segment of chromosome 15 in murine T-cell leukaemiaNature, 1978
- Chromosome Changes (Trisomies #15 and 17) Associated With Tumor Progression in Leukemias Induced by Radiation Leukemia Virus2JNCI Journal of the National Cancer Institute, 1978
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- Trisomy of chromosome 15 in spontaneous leukemia of AKR mice.Proceedings of the National Academy of Sciences, 1975
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