REVERSAL BY NALOXONE OF THE EFFECTS OF CHRONIC ADMINISTRATION OF DRUGS OF DEPENDENCE ON RAT LIVER AND BRAIN TRYPTOPHAN METABOLISM
Open Access
- 1 October 1981
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 74 (2) , 489-494
- https://doi.org/10.1111/j.1476-5381.1981.tb09995.x
Abstract
1 Chronic administration of ethanol, morphine, nicotine or phenobarbitone has previously been shown to enhance rat brain 5-hydroxytryptamine (5-HT) synthesis by increasing the availability of circulating tryptophan to the brain secondarily to the NADPH-mediated inhibition of liver tryptophan pyrrolase activity 2 Naloxone reverses the above enhancement of 5-HT synthesis and the accompanying increase in tryptophan availability to the brain and the inhibition of liver tryptophan pyrrolase activity 3 It is suggested that naloxone exerts these effects by antagonizing the chronic drug-induced increase in liver [NADPH] 4 Naloxone increases serum corticosterone concentration in rats chronically treated with the above four drugs of dependence. Possible explanations of this effect are discussed.Keywords
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