Use of Adjunctive Treatment with Interferon- in an Immunocompromised Patient Who Had Refractory Multidrug-Resistant Tuberculosis of the Brain
Open Access
- 1 March 1996
- journal article
- case report
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 22 (3) , 572-574
- https://doi.org/10.1093/clinids/22.3.572
Abstract
We describe a patient with acute lymphocytic leukemia and multidrug-resistant tuberculosis of the brain and spinal cord. Despite treatment with six antituberculous drugs and a steroid medication for 11 months, there was no appreciable clinical or radiological improvement in the patient's condition. Within 5 months of initiating adjunctive therapy with IFN-γ and granulocyte colony stimulating factors, substantial neurological and radiological improvement was noted. Therapy with IFN-γ was continued for 12 months, resulting in complete resolution of the lesions in the brain and spinal cord.Keywords
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