Susceptibility of Skeletal Muscle to Coxsackie A 2 Virus Infection: Effects of Botulinum Toxin and Denervation
- 17 February 1984
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 223 (4637) , 714-716
- https://doi.org/10.1126/science.6320369
Abstract
Coxsackie A viruses can infect denervated but not innervated mature skeletal muscles. The role of synaptic transmission in preventing susceptibility to Coxsackievirus infection was studied by surgically denervating leg muscles of mice or injecting the muscles with botulinum toxin to block quantal release of acetylcholine. Control muscles were injected with heat-inactivated toxin. Subsequent injection of Coxsackie A2 virus resulted in extensive virus replication and tissue destruction in the denervated and botulinum toxin-treated muscles, while the control muscles showed only minimal changes. This suggests that the susceptibility of skeletal muscle to Coxsackievirus infection is regulated by synaptic transmission.Keywords
This publication has 30 references indexed in Scilit:
- The roles of disuse and loss of neurotrophic function in denervation atrophy of skeletal muscleExperimental Neurology, 1981
- Effect of botulinum toxin on trophic regulation of acetycholine receptorsNature, 1976
- Botulinum Toxin: Mechanism of Presynaptic BlockadeScience, 1976
- Effects of the type A toxin fromClostridium botulinum on the development of skeletal muscles and of their innervation in chick embryoBrain Research, 1975
- SYSTEMS OF MATERIAL TRANSPORT IN NERVE FIBERS (AXOPLASMIC TRANSPORT) RELATED TO NERVE FUNCTION AND TROPHIC CONTROL*Annals of the New York Academy of Sciences, 1974
- THE ROLE OF ACETYLCHOLINE AS A NEUROTROPHIC TRANSMITTER*Annals of the New York Academy of Sciences, 1974
- Atrophy of Skeletal Muscle in Chick Embryos Treated with Botulinum ToxinScience, 1964
- THE MAMMALIAN CELL-VIRUS RELATIONSHIPThe Journal of Experimental Medicine, 1959
- NEUROPATHOGENICITY OF GROUP A COXSACKIE VIRUSESThe Journal of Experimental Medicine, 1957
- Catalase Assay with Special Reference to Manometric MethodsScience, 1953