Stilbazium Iodide as an Anthelmintic. II. Against Various Nematodes of Dogs and Cats

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Abstract
Stilbazium iodide was tested against three species of hookworms, three of round-worms and one of whipworm in 120 dogs and cats. Two or three 25 mg/kg base doses removed most Ancylostoma caninum, A. tubaeforme, Uncinaria stenocephala, Toxocara canis and T. cati; but Toxascaris leonina was more resistant. The drug is active against Trichuris vulpis in dogs when it is given in courses of 3 to 6 doses of 25 mg/kg base or higher. Two or more courses may be necessary for puppies and for dogs having narrow cecal openings or extensively coiled ceca. Except for five dogs with atypical ceca, 24 of 29 dogs given these multiple doses averaged over 90% elimination of whipworms with 18 of the 24 having complete clearance. Vomiting is negligible in these animals provided the dose is less than 50 mg/kg base. This compound is in human clinical trial against hookworms, ascaris, whipworms, and pinworms.

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