Sickle Cell Disease in a Brazilian Population from Sao Paulo: A Study of the βs Haplotypes
- 1 January 1994
- journal article
- research article
- Published by S. Karger AG in Human Heredity
- Vol. 44 (6) , 322-327
- https://doi.org/10.1159/000154238
Abstract
In this study we have determined the frequency of βs haplotypes in a Brazilian sickle cell disease population from Sao Paulo, Brazil, by analyzing sequence variations in the immediate 5’ flanking and second intervening sequence (IVSII) regions of the γ globin genes. This association between sequence differences and βs haplotype backgrounds was determined by screening genomic DNA samples using dot blot analysis of polymerase chain reaction products. We studied 148 βs chromosomes, and found that haplotype 20 (CAR or Bantu) significantly predominated in this population. This is in agreement with the findings of the historical Portuguese Atlantic slave trade from Africa to South America.Keywords
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