Comparison of the mode of action of prostaglandin E2 (PGE2) and sulprostone, a PGE2-derivative, on the lower urinary tract in healthy women

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Abstract
The influence of intravesical administration of PGE2 (1,500 μg) and sulprostone, a PGE2 derivative (1,000 μg) on urodynamic parameters of the lower urinary tract was tested on six healthy female patients. PGE2 and sulprostone significantly decreased the urethral closure pressure at rest. PGE2 increased the detrusor opening pressure as well as the detrusor pressure during maximum flow. Sulprostone, in contrast, slightly decreased these parameters. Both substances caused a strong urgency sensation resulting in an equally reduced bladder capacity and leading to a measurable bladder instability in both cases. This gives rise to the assumption that frequency, urgency and bladder instability may be the result of intravesical relaxation. By 24 h after administration all urodynamic parameters had returned to pretreatment values, thus indicating that long-term changes in urodynamic parameters are not found after either prostaglandin.