Platelet aggregation. Adult-onset diabetes mellitus and coronary artery disease

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Abstract
Using a turbidimetric technique, 1.7 .mu.M ADP-induced platelet aggregation and disaggregation at 37.degree. C in the platelet-rich plasmas of 2 groups of men with coronary artery disease was determined. Eleven men were nondiabetic and 11 had adult-onset diabetes mellitus without retinopathy. There were no significant differences (P > .05) between diabetics and nondiabetics of the following variables: age, platelet count in platelet-rich plasma, 1st and 2nd phases of platelet aggregation, maximum extent of aggregation and percent disaggregation at 3 min after maximum aggregation occurred. Although the mean ADP-induced platelet aggregation in the platelet-rich plasmas of adult-onset diabetic men with coronary artery disease and no retinopathy was not enhanced, and the mean rate of disaggregation was not reduced, when compared with nondiabetic men with coronary artery disease or with healthy men; a slow rate of platelet disaggregation (less than 10%) occurred more frequently in the platelet-rich plasmas of men with coronary artery disease.

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