Some Factors Associated with the Development of Coronary Heart Disease—Six Years' Follow-Up Experience in the Framingham Study

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Abstract
Data are presented on the association between several socio-economic factors and the development, during a 6-year period, of coronary heart disease (CHD) in a randomly selected adult population. During the 6-years of follow-up an inverse association with educational status was noted, the incidence of CHD being less at higher educational levels. There was no association between national origin and the risk of CHD. Smoking was associated with an increased risk of both non-fatal myocardial infarction and of death from CHD in men aged 45-62 years. But it was not associated with an increased incidence of angina pectoris. Cholesterol levels were noted to be higher among cigarette smokers than among non-smokers and higher among those who had smoked and stopped than among those who had never smoked. Neither weight nor blood pressure showed any association with smoking. Alcohol consumption was not associated with CHD although heavy alcohol intake was associated with heavy smoking. A suggestively low incidence of CHD was noted in one of 8 Framingham precincts. This precinct differed from the others in some respects, but no explanation of this finding can as yet be offered.

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