59Fe and 51Cr Studies in Aplastic Anaemia and Myelosclerosis

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Abstract
Iron utilization and erythropoiesls were studied using 59Fe and 51Cr in 13 patients with aplastic anemia and 10 patients with myelosclerosls. In aplastic anemia the 59Fe clearance was either rapid or slow, its incorporation into circulating red cells was low and the plasma Fe turnover was elevated. The survival of circulating red cells was slightly reduced. Body surface measurements did not reveal a predominant involvement of the spleen in the hemolysls. In myelosclerosls the 59Fe clearance was rapid, its incorporation into circulating red cells was low or slightly below normal and the plasma Fe turnover was increased. Surface measurements showed extramedullary erythropoiesls in all cases. Two of the 3 patients studied showed a short red cell survival time, with an involvement of the spleen in the destruction of red cells.

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