Antibiotic sensitivity patterns of penicillinase-positive and penicillinase-negative strains of Neisseria gonorrhoeae isolated in Fukuoka, Japan.

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Abstract
Penicillinase production and minimum inhibitory concentrations (MIC) of penicillin G, amoxycillin, doxycycline and spectinomycin were studied for 155 gonococcal strains isolated in Fukuoka, Japan, April-Dec. 1981. Of 155 isolates, 25 (16.1%) strains were identified as penicillinase-producing N. gonorrhoeae (PPNG) by a rapid iodometric test. The antibiotic sensitivity of 130 penicillinase-negative (non-PPNG) and 25 PPNG strains was compared. The mean MIC of penicillin G for non-PPNG strains was 0.65 .mu.g/ml. The 25 PPNG strains had penicillin G MIC of 6.25 - > 100 .mu.g/ml. The susceptibility to amoxycillin and doxycycline of PPNG strains was significantly lower than that of non-PPNG strains. All the strains were sensitive to spectinomycin. The MIC of 4 antibiotics for non-PPNG strains were significantly correlated.