k-Opioid diuretic effects of tifluadom, a benzodiazepine opioid agonist
- 1 August 1984
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 36 (8) , 555-556
- https://doi.org/10.1111/j.2042-7158.1984.tb04453.x
Abstract
Tifluadom produced a dose-related (0·08–5 mg kg−1) diuresis in normally hydrated rats. This diuretic effect was antagonized by k-antagonist doses of naloxone and blocked by morphine administration. This is further in-vivo evidence that tifluadom is a fairly specific k-opioid agonist.Keywords
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