Childhood malignant tumors. Concurrent chemotherapy with dactinomycin and vincristine sulfate

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Abstract
Dactinomycin and vincristine sulfate were administered concurrently to 18 children with inoperable malignant solid tumor. Objective tumor regression was observed in 6 of 6 children with embryonal rhabdomyosarcoma, 3 of 3 with Wilms'' tumor, 2 of 2 with mesonephroma, 2 of 2 with malignant teratoma, and one each with adenocarcinoma of the pancreas and primary carcinoma of the liver. One child with osteogenic sarcoma, one with an embryonal carcinoma, and one with a reticulum cell sarcoma failed to respond to the drug. The toxic effects produced by the concurrent chemotherapy in this group of children were mild and transient. No serious neurotoxicity or bone marrow depression were encountered. The results of this study indicate that full therapeutic dosages of dactinomycin and vincristine sulfate can be administered concurrently to children without serious toxicity and that when used in this manner the antitumor effects of the 2 drugs may be additive.

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