HYPOMETHYLATION OF C-MYC AND EPIDERMAL GROWTH-FACTOR RECEPTOR GENES IN HUMAN HEPATOCELLULAR-CARCINOMA AND FETAL LIVER

  • 1 December 1985
    • journal article
    • research article
    • Vol. 76  (12) , 1136-1140
Abstract
The methylation state of cellular oncogenes (c-oncs) and epidermal growth factor (EGF) receptor gene from human liver tissues was examined by means of restriction endonuclease analysis. c-myc and EGF receptor gene from hepatocellular carcinoma and fetal liver were substantially hypomethylated in comparison with those genes from normal liver, while the extents of methylation of c-mos and c-Ki-ras genes were the same among these tissues. It can be speculated that the specific hypomethylation of c-myc and EGF receptor genes may be associated with the development of hepatocellular carcinoma.