Preparation of quinolines by reduction of ortho-nitroarenes with zinc in near-critical water
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in New Journal of Chemistry
- Vol. 23 (6) , 641-643
- https://doi.org/10.1039/a902554e
Abstract
We report a preparation of quinoline 2 and indole 4 derivatives by reduction of suitably functionalised o-nitroarenes with Zn powder in H2O at 250°C. The process involves the reduction of the nitro group to an amino group followed by insitu cyclisation with a carbonyl or alcohol moiety in an aqueous medium. The amount of hydroquinoline 3 produced depends on the nature of the carbonyl moiety of the nitroarene.Keywords
This publication has 0 references indexed in Scilit: