General routes to 4-methyl-2-substituted-furans: a total synthesis of pleraplysillin-2, a metabolite of the sponge, Pleraplysilla spinifera
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 3,p. 679-683
- https://doi.org/10.1039/p19810000679
Abstract
A general approach to 4-methyl-2-substituted-furans is described in which 4-methyl-2-furyl-lithium is the key intermediate. Using this method, pleraplysillin-2, a sesquiterpenoid ester from the sponge Pleraplysilla spinifera, has been synthesised. An alternative, less efficient, route to this type of furan, via acyclic keto-epoxides, is also discussed.This publication has 1 reference indexed in Scilit:
- Polyacetylenverbindungen, 246: Synthese von Acetylenverbindungen aus Alphonsea ventricosaEuropean Journal of Inorganic Chemistry, 1978