The influence of diuretics on the excretion and metabolism of doping agents part iv—caffeine

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Abstract
The urinary excretion of caffeine in humans was followed over a period of 36 h after the oral administration of ANIMINE®, a formulation containing caffeine‐α‐naphthylacetate.The excretion of caffeine was not as markedly affected by the urinary pH as was found with stimulant amines. Excretion peaks were obtained 1‐2 h after the ingestion and the total amount of unchanged caffeine excreted during 12 h varied from 0.57 to 1.51 per cent.The ingestion of the diuretics acetazolamide or furosemide 2 h after caffeine resulted in a urine‐flow dependent and consequently increased caffeine excretion during 2–4 h post‐diuretic. This increase paralleled the increase in urine volume resulting in no meaningful differences in caffeine concentration compared to normal conditions.