The Inhibition of Platelet Aggregation by Biscoclaurine Alkaloids

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Abstract
The effects of biscoclaurine alkaloids on ADP- or collagen-induced human platelet aggregation were exmained as alkaloids are known to inhibit lipid peroxidation and stabilize labilized biomembranes. Most alkaloids greatly inhibit the platelet aggregation induced by ADP or collagen. This inhibition was concentration dependent and significantly higher where there was collagen aggregation. Alkaloids studied included the following: dauricine, cepharanthine, homoaromoline, berbamine, tetrandrine, fangchinoline, isotrilobine, cycleanine, N-methyl coclaurine, and papaverine.