Antimitotic Activity of the Potent Tumor Inhibitor Maytansine
- 19 September 1975
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 189 (4207) , 1002-1005
- https://doi.org/10.1126/science.1241159
Abstract
Maytansine, at 6x10(-8)M, irreversibly inhibits cell division in eggs of sea urchins and clams. It causes the disappearance of a mitotic apparatus or prevents one from forming if added at early stages. Maytansine does not affect formation of the mitotic organizing center but does inhibit in vitro polymerization of tubulin. Maytansine and vincristine inhibit in vitro polymerization of tubulin at about the same concentrations, but vincristine is about 100 times less effective as an inhibitor of cleavage in marine eggs.Keywords
This publication has 16 references indexed in Scilit:
- REGULATION OF THE IN VIVO MITOTIC APPARATUS BY GLYCOLS AND METABOLIC INHIBITORS*Annals of the New York Academy of Sciences, 1975
- In vitro polymerization of microtubules into asters and spindles in homogenates of surf clam eggs.The Journal of cell biology, 1975
- Turbidimetric studies of the in vitro assembly and disassembly of porcine neurotubulesJournal of Molecular Biology, 1974
- Role of surface alterations in cell transformation: the importance of proteases and surface proteinsCell, 1974
- Regulation of size and birefringence of the in vivo mitotic apparatusJournal of Supramolecular Structure, 1974
- Microtubule Formation in vitro in Solutions Containing Low Calcium ConcentrationsScience, 1972
- Augmentation and dispersion of thein vivo mitotic apparatus of living marine eggsProtoplasma, 1969
- The DNA synthetic period during early development of the sea urchin eggExperimental Cell Research, 1964
- STUDIES OF EARLY CLEAVAGE IN THE SURF CLAM, SPISULA SOLIDISSIMA, USING METHYLENE BLUE AND TOLUIDINE BLUE AS VITAL STAINSThe Biological Bulletin, 1959
- THE ACTION OF PODOPHYLLIN AND ITS FRACTIONS ON MARINE EGGSAnnals of the New York Academy of Sciences, 1951