A minimal stochastic model for influenza evolution
- 1 July 2005
- journal article
- Published by IOP Publishing in Journal of Statistical Mechanics: Theory and Experiment
- Vol. 2005 (07) , P07008
- https://doi.org/10.1088/1742-5468/2005/07/p07008
Abstract
We introduce and discuss a minimal individual-based model for influenza dynamics. The model takes into account the effects of specific immunization against viral strains, but also infectivity randomness and the presence of a short-lived strain transcending immunity recently suggested in the literature. We show by simulations that the resulting model exhibits substitution of viral strains along the years, but that their divergence remains bounded. We also show that dropping any of these features results in a drastically different behavior, leading either to the extinction of the disease, to the proliferation of the viral strains, or to their divergence.Keywords
All Related Versions
This publication has 17 references indexed in Scilit:
- The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virusProceedings of the National Academy of Sciences, 2004
- Influenza drift and epidemic size: the race between generating and escaping immunityTheoretical Population Biology, 2004
- Unifying the Epidemiological and Evolutionary Dynamics of PathogensScience, 2004
- Dynamics of annual influenza A epidemics with immuno-selectionJournal of Mathematical Biology, 2003
- Ecological and immunological determinants of influenza evolutionNature, 2003
- Ecology and evolution of the fluTrends in Ecology & Evolution, 2002
- Simple model of epidemics with pathogen mutationPhysical Review E, 2002
- Coevolution of Quasispecies: B-Cell Mutation Rates Maximize Viral Error CatastrophesPhysical Review Letters, 2002
- Effects of passage history and sampling bias on phylogenetic reconstruction of human influenza A evolutionProceedings of the National Academy of Sciences, 2000
- Predicting the Evolution of Human Influenza AScience, 1999