Acute Direct Adenoviral Vector Cytotoxicity and Chronic, but Not Acute, Inflammatory Responses Correlate with Decreased Vector-Mediated Transgene Expression in the Brain
Open Access
- 1 January 2001
- journal article
- Published by Elsevier in Molecular Therapy
- Vol. 3 (1) , 36-46
- https://doi.org/10.1006/mthe.2000.0224
Abstract
No abstract availableKeywords
This publication has 26 references indexed in Scilit:
- Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: Toward realistic long-term neurological gene therapy for chronic diseasesProceedings of the National Academy of Sciences, 2000
- Phase I Study of Adenoviral Delivery of the HSV-tk Gene and Ganciclovir Administration in Patients with Recurrent Malignant Brain TumorsMolecular Therapy, 2000
- Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trialsNature Medicine, 1999
- A model for long-term transgene expression in spinal cord regeneration studiesGene Therapy, 1999
- Induction of apoptosis and G2/M arrest by infection with replication-deficient adenovirus at high multiplicity of infectionGene Therapy, 1999
- Interleukin-1 Mediates a Rapid Inflammatory Response After Injection of Adenoviral Vectors into the BrainJournal of Neuroscience, 1999
- Analysis of Events Leading to Neuronal Death after Infection with E1-Deficient Adenoviral VectorsMolecular and Cellular Neuroscience, 1998
- Immune Responses to Reporter Proteins and High Viral Dose Limit Duration of Expression with Adenoviral Vectors: Comparison of E2a Wild Type and E2a Deleted VectorsHuman Gene Therapy, 1997
- Intracranial Administration of Adenovirus Expressing HSV-TK in Combination with Ganciclovir Produces a Dose-Dependent, Self-Limiting Inflammatory ResponseHuman Gene Therapy, 1997
- Adenovirus gene transfer causes inflammation in the brainNeuroscience, 1995