Genomic structure of the mouse A-type lamin gene locus encoding somatic and germ cell-specific lamins
- 29 May 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 365 (2-3) , 108-114
- https://doi.org/10.1016/0014-5793(95)00453-g
Abstract
Mouse A-type lamin genes were isolated. Structural analyses revealed that all the three known mouse A-type lamins (A, C and C2) were coded in a single genomic locus in a 22 kilobase DNA segment. The three lamins were coded in 12, 10 and 10 exons for A, C and C2, respectively, and shared 8 exons among them. Primer extension analyses identified possible transcription start sites for both A/C and C2 genes suggesting that the locus is under the control of two separate promoters, that is a somatic cell-acting promoter (for A and C) and a testis-specific promoter (for C2) which resides in the first intron of the A/C gene. Sequence characteristics of the possible promoter regions are discussed. Divergence of the two somatic cell-type lamins (A and C) is formally accounted for by differential selection of poly(A) sites together with lamin A-specific splicingKeywords
This publication has 26 references indexed in Scilit:
- Dynamic properties of nuclear lamins: lamin B is associated with sites of DNA replication.The Journal of cell biology, 1994
- INTERMEDIATE FILAMENTS: Structure, Dynamics, Function and DiseaseAnnual Review of Biochemistry, 1994
- Identification and Cloning of an mRNA Coding for a Germ Cell-Specific A-Type Lamin in MiceExperimental Cell Research, 1994
- Assembly and cell cycle dynamics of the nuclear laminaSeminars in Cell Biology, 1992
- Network antibodies identify nuclear lamin B as a physiological attachment site for peripherin intermediate filamentsCell, 1991
- Protein chemical analysis of purified murine lamin B identifies two distinct polypeptides B1 and B2FEBS Letters, 1990
- Functional Organization of the Nuclear EnvelopeAnnual Review of Cell Biology, 1988
- Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin BCell, 1987
- Nuclear lamins and cytoplasmic intermediate filament proteins: A growing multigene familyCell, 1987
- Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteinsNature, 1986