Dose‐response studies with pancuronium, vecuronium and their combination.
Open Access
- 1 December 1984
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 18 (6) , 947-950
- https://doi.org/10.1111/j.1365-2125.1984.tb02568.x
Abstract
Pancuronium, vecuronium and a combination of these were administered in an incremental fashion to study any potentiation of effect with the combination of the two relaxants. The ED95 (dose producing a 95% block) of the combination was 29 micrograms kg-1 for each component in comparison to 57 micrograms kg-1 for vecuronium and 59 micrograms kg-1 for pancuronium. The dose-response curves for the three groups did not differ from each other and no potentiation was demonstrated.This publication has 9 references indexed in Scilit:
- Time Course of Muscle Relaxation with a Combination of Pancuronium and TubocurarineAnesthesia & Analgesia, 1984
- Competitive Nonspecific Binding Does Not Explain the Potentiating Effects of Muscle Relaxant CombinationsAnesthesia & Analgesia, 1983
- COMBINATION OF PANCURONIUM AND METOCURINE - NEUROMUSCULAR AND HEMODYNAMIC ADVANTAGES OVER PANCURONIUM ALONE1981
- Combination of Pancuronium and MetocurineAnesthesia & Analgesia, 1981
- Potentiation of Neuromuscular Blockade in Man Produced by Combinations of Pancuronium and Metocurine or Pancuronium and d-TubocurarineAnesthesia & Analgesia, 1980
- The Emergence of ORG NC 45, 1- [(2β,3α, 5α,16β, 17β)-3, 17-BIS(Acetyloxy)-2-(1-Piperidinyl)-Androstan-16-YL]-1-Methylpiperidinium Bromide, from the Pancuronium SeriesBritish Journal of Anaesthesia, 1980
- The Neuromuscular Blocking Action of ORG NC 45, A New Pancuronium Derivative, in Anaesthetized PatientsBritish Journal of Anaesthesia, 1980
- The interaction between d-tubocurarine and gallamine during halothane anaesthesiaCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1972
- Some Synergistic Effects of d-Tubocurarine and GallamineAnesthesia & Analgesia, 1971