Treating Cancer by Targeting a Weakness
- 1 September 2005
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 353 (9) , 949-950
- https://doi.org/10.1056/nejmcibr052331
Abstract
Most targeted therapies for cancer are designed to bind a specific protein expressed by cancer cells. Two recent studies indicate that a new approach may work: attacking a tumor at its weak spot.Keywords
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- Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient miceThe EMBO Journal, 2001