Antiandrogenic Substances in the Management of Prostatic Cancer

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Abstract
Antiandrogens are substances which counteract the effect of exogenous or endogenous hormones at target cells independently of feedback mechanisms. Because of the difficulty in ruling out activity exerted due to the influence on feedback mechanisms, antihormones are usually tested under experimental conditions allowing the exclusion of feedback. In the example of antiandrogens this means that an antiandrogen is a substance which counteracts the effect of exogenous androgens in castrated animals. Antiandrogens probably exert their action at the target cell level by competing with androgens for receptor binding sites and by inhibiting the translocation of the hormone receptor complex into the nucleus (Neri 1977; Brinkmann et al. 1983).