A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
- 22 May 2005
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 37 (6) , 590-592
- https://doi.org/10.1038/ng1571
Abstract
We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.Keywords
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