Metabotropic glutamate receptors: an original family of G protein‐coupled receptors
- 1 December 1993
- journal article
- review article
- Published by Wiley in Fundamental & Clinical Pharmacology
- Vol. 7 (9) , 473-485
- https://doi.org/10.1111/j.1472-8206.1993.tb00252.x
Abstract
In 1985, we discovered a new glutamate receptor which was coupled to phospholipase C via a G protein and which was later termed metabotropic glutamate receptor (mGluR). In this review, both the diversity of mGluRs and the cellular events they control are discussed, as well as their roles in physiological regulation and brain function.Keywords
This publication has 69 references indexed in Scilit:
- 4-Carboxy-3-hydroxyphenylglycine, an antagonist at type I metabotropic glutamate receptors: European Journal of Pharmacology — Molecular Pharmacology Section, 245 (1993) 299–301European Journal of Pharmacology: Molecular Pharmacology, 1993
- Competitive antagonism at metabotropic glutamate receptors by (S) -4-carboxyphenylglycine and (RS) -α-methyl-4-carboxyphenylglycineEuropean Journal of Pharmacology: Molecular Pharmacology, 1993
- A retrograde step forwardNature, 1992
- Cloning, expression and modulation of a mouse NMDA receptor subunitFEBS Letters, 1992
- Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)- and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysisEuropean Journal of Pharmacology: Molecular Pharmacology, 1991
- Activation of a Large‐conductance Ca2+‐Dependent K+ Channel by Stimulation of Glutamate Phosphoinositide‐coupled Receptors in Cultured Cerebellar Granule CellsEuropean Journal of Neuroscience, 1991
- A long-term depression of AMPA currents in cultured cerebellar purkinje neuronsNeuron, 1991
- Pharmacological characterization of the quisqualate receptor coupled to phospholipase C (Qp) in striatal neuronsEuropean Journal of Pharmacology: Molecular Pharmacology, 1991
- A potent metabotropic glutamate receptor agonist: electrophysiological actions of a conformationally restricted glutamate analogue in the rat spinal cord and Xenopus oocytesBrain Research, 1990
- Protein kinases, nitric oxide and long-term depression of synapses in the cerebellumNeuroReport, 1990