The Relationship of X-Ray Induced Recessive Lethals to Chromosomal Breakage

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Abstract
Employing the C1B technique, recessive lethal changes were obtained in the Canton S stock of Drosophila melanogaster after x-ray dosage at 1000r and 5000r. Lethal cultures were then tested in a crossover generation for their association with chromosomal rearrangements. These were detected by a reduction in crossing over of 50% or more in either or both regions of the X chromosome tested. Of the F2 cultures 0.3 [plus or minus] 0.21% at 1000r and 3.57 [plus or minus] 1.3% at 5000r showed lethals associated with the region of chromosomal rearrangement. Of 43 recessive lethals tested, none showed chromosomal rearrangements unassociated with a lethal. Analysis of the available data suggests x-ray induced lethals are produced primarily at breakage points and relegate to position effect and non-breakage mutation a relatively small part as sources of recessive lethals.

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