Lipoprotein secretion by isolated perfused livers from streptozotocin-diabetic rats
- 1 October 1981
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 21 (4) , 402-408
- https://doi.org/10.1007/bf00252689
Abstract
In liver perfusion from sucrose-fed, streptozotocin-diabetic rats there was in comparison with normal animals, a decrease in very low density lipoprotein concentration in the perfusion medium (38.6 ±6.3 versus 64.4±8.4 μg · g liver -1 3h-1, p -1 3h-1, p3H-leucine: 14C-glucosamine incorporation was decreased in all diabetic lipoprotein classes suggesting increased glycosylation of apoproteins. These changes in particle composition may influence lipoprotein metabolism in diabetes through their effects on lipoprotein lipase and lecithin cholesterol acyl transferase activity, plasma half-life and tissue binding.Keywords
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