Time-Delay for Two-Compartment Models Used for Study of Enterohepatic Circulation of Drugs
- 1 June 1984
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Biomedical Engineering
- Vol. BME-31 (6) , 469-472
- https://doi.org/10.1109/TBME.1984.325414
Abstract
A two-component model with time lag was proposed to describe pharmacokinetics of drugs subject to enterohepatic circulation. An analytic expansion of the amount of drug, at any time, in the central compartment after an intravenous bolus, or an oral intake, or a constant infusion, from a zero or nonzero equilibrium is given. By computer simulations, plasma level profiles are obtained and lead to rebounds and secondary peaks, according to experimental evidences.Keywords
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