Hypodipsic Hypernatremia with Normal Osmoregulation of Vasopressin

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Abstract
HYPODIPSIC hypernatremia is an uncommon syndrome that has been observed in children and adults with various congenital or acquired diseases of the brain.1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 The syndrome is characterized by chronic or recurrent episodes of severe hypernatremia associated with dehydration and a lack of thirst. In all previous carefully evaluated cases, hypodipsia has been associated with some defect in secretion of the antidiuretic hormone arginine vasopressin.1 , 3 , 5 , 7 , 9 10 11 12 13 14 15 16 17 , 19 , 21 22 23 24 25 26 Often, the defect in secretion of vasopressin is clinically inapparent and can be demonstrated only by assay of the hormonal response to osmotic stimulation or suppression.1 , 7 , 15 16 17 , 19 , 23 24 25 26 This constellation of deficits suggests that the syndrome is due . . .