ROLE OF ANTIBACTERIAL PREPARATION OF INTESTINE IN REDUCTION OF PRIMARY WOUND SEPSIS AFTER OPERATIONS ON COLON AND RECTUM

  • 1 January 1978
    • journal article
    • research article
    • Vol. 147  (6) , 909-912
Abstract
A consecutive series of 320 patients undergoing operations on the colon and rectum, under the care of 1 surgeon, was studied to determine the influence of oral antibacterial preparation of the intestine on the incidence of postoperative wound sepsis. Thirty patients were excluded from the analysis and the rates of major wound sepsis, in the remaining 290 patients were 21.7% when no antibacterial preparation was used; 18.6% when the intestine was prepared with phthalylsulfathiazole and neomycin, and 1.6% when the intestine was prepared with phthalylsulfathiazole, neomycin and tetracycline. Other important determinants of the rate of wound sepsis were obesity and the use of cephaloridine prophylaxis. Results of bacteriologic studies showed the effectiveness of triple antimicrobial preparation of intestine against gram-negative aerobes and Bacteroides spp.

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