Plasma Renin Activity in Segmental Hypoplasia of the Kidneys with Hypertension

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Abstract
The plasma renin activity (PRA) was measured by radioimmunoassay in 15 children with segmental hypoplasia of the kidneys and hypertension. PRA values in peripheral blood on recumbency and regular sodium intake were normal in 5 out of 8 cases. In 4 out of 6 cases the PRA levels were not suppressed by sodium loading. In one patient with bilateral segmental hypoplasia, terminal renal failure and malignant hypertension, PRA was extremely high. After bi-nephrectomy, blood pressure was rapidly reduced. In one patient with strictly unilateral segmental hypoplasia, renal vein PRA measurements suggested an increased renin secretion by the affected kidney. In five other patients, PRA in renal veins was normal. From these data, it is suggested that the renin-angiotensin system plays a role in the pathophysiology of the hypertension in some forms of segmental hypoplasia of the kidneys.

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