Effect of Monoglycerides on Absorption of Cholesterol from the Intestine and Turnover Rate of Cholesterol Esters in Plasma and Liver of the Rat.

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Abstract
Absorption and transport of cholesterol were studied in rats with gastric and venous cannula. These studies were made on individual experimental animals by periodically sampling the blood of the same animal. Absorption of cholesterol from the intestine depends upon the degree of saturation of the dietary fat available in the intestine. More cholesterol is absorbed when polyunsaturated fat is present than when saturated fat is present in the intestinal lumen. Analyses of individual cholesterol esters in the plasma of rats show a gradual increase in the specific activity (counts per minute per milligram) of the cholesteryl palmitate fraction and to some degree the cholesteryl oleate as a function of time, while, on the other hand, the cholesteryl linoleate and cholesteryl arachidonate showed a gradual decrease in specific activity within a few hours after administration of the radioactive cholesterol. This pattern was observed regardless of whether glyceryl-monostearate, glyceryl-monooleate or glyceryl monolinoleate was fed and this suggests that the polyunsaturated cholesterol esters such as cholesteryl linoleate or cholesteryl arachidonate have a faster turnover rate than cholesteryl oleate or cholesteryl palmitate which have a relatively slow turnover rate.

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