THE GENETIC FACTOR IN OTOSCLEROSIS

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Abstract
PART I. PROBLEM, METHODS OF STUDY AND RESULTS A. STATEMENT OF PROBLEM 1.Definition of Otosclerosis.—Otosclerosis may, for the purpose of this study, be defined as a process of change in the bony structure of the otic capsule, located in the petrous portion of the temporal bone (labyrinthine capsule). The changes usually involve, first, an ossification of the annular membrane connecting the margin of the base of the stapes and the margin of the fenestra ovalis (which is closed by the base of the stapes), so that the stapes is firmly ankylosed to the margin of the fenestra ovalis. They lead, ordinarily, to a progressive hardness of hearing. In recent years the bony changes in otosclerosis have been found to be even more widespread in the petrosal bone than was formerly recognized. Large hollow spaces arise in the bone, which has pathologically enlarged blood vessels and a

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