Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain
- 15 April 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 196 (4287) , 326-328
- https://doi.org/10.1126/science.847477
Abstract
Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25% increase in striatal dopamine receptor binding assayed with [3H]haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.Keywords
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