Metabolic Responsiveness of Human Leukemic Leukocytes to Phagocytic Stimulation

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Abstract
Metabolic activities of human leukocytes obtained from normal blood and various types of leukemia and the metabolic changes by the addition of bacilli were studied. Increase of oxygen uptake as well as the activation of hexose monophosphate shunt were observed during phagocytosis of normal leukocytes. These metabolic changes were highest in normal leukocytes and varied in degree with the different types of leukemic leukocytes, depending upon the number of cells capable of phagocytosis. The more mature the cells, the greater the glycolytic rates. On the contrary, the lipid turnover rates were inversely proportional to cell maturity. Lymphatic cells exhibited low metabolic rates of glycolysis and lipid turnover.

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