ANTI-ALLERGIC PROPERTIES OF ETHYL-3-METHOXYPHENYL-4-THIAZOLYL-2-OXAMATE (F-1865)

  • 1 January 1982
    • journal article
    • research article
    • Vol. 260  (1) , 165-176
Abstract
F 1865 (ethyl-3-methoxyphenyl-4-thiazolyl-2-oxamate) has powerful oral antiallergic properties in immediate hypersensitivity models in rats. In IgE-dependent passive cutaneous anaphylaxis (PCA), the ED50 was 0.8 mg/kg. In IgG-dependent PCA, the ED50 was 0.6 mg/kg. This oxamate derivative inhibited the liberation of histamine during passive peritoneal anaphylaxis in rats at concentrations of 1 .times. 10-6 M or higher. Doses of F 1865, active in PCA, had only weak antihistamine and antiserotonin effects, as measured by the increase of cutaneous capillary permeability. Its inhibitory effect on the bronchospasm due to histamine or serotonin in guinea pigs was apparent only at doses of 1 mg/kg on i.v. administration. At doses of 100 mg/kg (.times.2) p.o. [orally], F 1865 was inactive against reverse passive Arthus pleurisy induced in rats by rabbit anti-bovine-albumin serum.

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