Heterogeneity in the IgE Binding to a Peptide Derived from the House Dust Mite Allergen Der p II Indicates that the IgE Response Is Highly Polyclonal
- 1 January 1993
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 101 (4) , 437-441
- https://doi.org/10.1159/000236488
Abstract
The fine specificity of IgE antibody binding to peptide 65-78 of the house dust mite major allergen Der p II was examined by comparison with binding to two peptides in which the cysteines corresponding to cys73 and cys78 in Der p II were substituted by serines and methionines. Differences in binding behavior indicated that at least three different subpopulations of IgE antibodies bound to peptide 65-78. Even at the level of such a small fragment the IgE response in individual donors proved to be polyclonal.Keywords
This publication has 0 references indexed in Scilit: