The release of 5-hydroxytryptamine from the rat stomachin vitro

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Abstract
5-HT [5-hydroxytryptamine] was released into the lumen of the intact isolated rat stomach and into the bath fluid surrounding a preparation of the body and antrum stretched mechanically. Release of 5 -HT increased when the pressure inside the intact stomach was raised or when the body/antrum preparation was stretched. This increased release was nt prevented by hexamethonium, atropine, hyoscine or procaine, and was probably due to distortion of cells containing 5-HT. During periods of peristalsis induced by transmural stimulation the pharmacological activity of the fluid in the stomach was usually increased owing to a greater release of 5-HT and also to the release of an unidentified substance. In reserpine-treated rats, 5 -HT was released into the stomach but transmural stimulation did not produce true peristalsis and only rhythmic contractions occurred. Peristalsis was seldom reduced by methysergide, and it is concluded that 5-HT is not essential for gastric peristalsis in the rat.