Maturation by LctT Is Required for Biosynthesis of Full-Length Lantibiotic Lacticin 481

Open Access

1 January 2005

journal article
Published by American Society for Microbiology in Applied and Environmental Microbiology

Vol. 71 (1) , 562-565
https://doi.org/10.1128/aem.71.1.562-565.2005

Abstract

In lantibiotic lacticin 481 biosynthesis, LctT cleaves the precursor peptide and exports mature lantibiotic. Matrix-assisted laser desorption ionization-time of flight mass spectrometry revealed that a truncated form of lacticin 481 is produced in the absence of LctT or after cleavage site inactivation. Production of truncated lacticin 481 is 4-fold less efficient, and its specific activity is about 10-fold lower.

Keywords

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