A comparison of the incorporation of model steroids into non-ionic micellar and microemulsion systems
- 1 February 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 45 (2) , 141-143
- https://doi.org/10.1111/j.2042-7158.1993.tb03700.x
Abstract
The incorporation of testosterone and two of its esters, and progesterone and one of its esters (log Poct varying from 3·3 to 6·9) into 2% w/w soybean oil/Brij 96 microemulsions and Brij 96 surfactant systems has been examined. Possible sites of incorporation have been investigated. The drug carrying improvement of an oil-in-water microemulsion over a micellar system appears to depend on the solubility of the drug in the dispersed oil phase and is significant only for very lipophilic drugs.Keywords
Funding Information
- Royal Pharmaceutical Society of Great Britain
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