Induction of Antibody to the “y” Determinant of HBsAg in a Chimpanzee Carrier of HBsAg Subtype “adw”
Open Access
- 1 November 1976
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 117 (5_Part_2) , 2038-2040
- https://doi.org/10.4049/jimmunol.117.5_part_2.2038
Abstract
Summary: Antibody to the y determinant of hepatitis B surface antigen (HBsAg) was induced in a chimpanzee chronically infected with hepatitis B virus and circulating HBsAg subtype adw. The chimpanzee was immunized with purified preparations of HBsAg subtypes adw and ayw. Six weeks after immunization, antibody to HBsAg (anti-HBs), specific for the y determinant, appeared. No change occurred in titers of HBsAg or antibody to hepatitis B core antigen (anti-HBc), and “e” antigen remained detectable. The circulating HBsAg subtype adw remained present despite the persistence of anti-y for greater than 8 months.Keywords
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