Prognostic Features in Infants With Obstructive Uropathy Due to Posterior Urethral Valves

Publisher Website
Google Scholar
Abstract
The histories of 22 infants presented during the 1st yr of life with obstructive uropathy due to posterior urethral valves were analyzed to determine outcome and prognostic features. Mean patient age at the time of the initial surgical intervention was 39 days; the mean duration of follow-up inclusive of renal function data was 5.8 yr. One patient died (5%) and 1 had end stage renal disease. The mean preoperative and postoperative serum creatinine concentrations during the initial hospitalization were 3.1 and 1.4 mg/dl., respectively. Neither value was significantly predictive of the creatinine concentration at final follow-up. In contrast, the nadir creatinine value during the first year of life correlated significantly with final renal function. Children with nadir creatinine values .ltoreq. 0.8 mg/dl. by 12 mo of age maintained creatinine levels .ltoreq. 1.1 mg/dl. at the time of final evaluation; children with higher values during the 1st year of life were likely to have progressive renal failure. Of 19 final creatinine determinations 6 were normal and 5 exceeded 1.5 mg/dl. Proteinuria, hypertension, renal biopsy findings, urinary infection, unilateral nephrectomy and type of surgery did not correlate significantly with functional outcome. Follow-up studies of longer duration are needed to determine the ultimate outcome of these patients, more than half of whom had some degree of renal insufficiency at final evaluation.

This publication has 16 references indexed in Scilit: