Haloperidol: Effect of Long-Term Treatment on Rat Striatal Dopamine Synthesis and Turnover
- 8 July 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 197 (4299) , 181-183
- https://doi.org/10.1126/science.17917
Abstract
The short- and long-term effects of neuroleptic drugs differ both clinically and biochemically. Short-term treatment with such a drug causes a kinetic activation of striatal tyrosine hydroxylase. Long-term treatment causes a prompt activation of the enzyme which is followed by a delayed, compensatory deactivation below control levels. Tolerance also develops to the stimulating effect of haloperidol on striatal dopamine turnover.This publication has 26 references indexed in Scilit:
- Conjugated 3,4 dihydroxy phenyl acetic acid (DOPAC) in human and monkey cerebrospinal fluid and rat brain and the effects of probenecid treatmentLife Sciences, 1976
- Evidence for the lack of direct phosphorylation of bovine caudate tyrosine hydroxylase following activation by exposure to enzymatic phosphorylating conditionsBiochemical and Biophysical Research Communications, 1975
- Changes of kinetic constant of striatal tyrosine hydroxylase elicited by neuroleptics that impair the function of dopamine receptorsBrain Research, 1974
- In vivo enhancement of tyrosine hydroxylation in rat striatum by tetrahydrobiopterinNature, 1974
- Tolerance phenomena with neuroleptics catalepsy, apomorphine stereotypies and striatal dopamine metabolism in the rat after single and repeated administration of loxapine and haloperidolEuropean Journal of Pharmacology, 1973
- Effects of some psychotropic drugs on tyrosine hydroxylase activity in different structures of the rat brainEuropean Journal of Pharmacology, 1973
- Involvement of Adenosine 3′,5′-Monophosphate in the Activation of Tyrosine Hydroxylase Elicited by DrugsScience, 1973
- Regional distribution of tyrosine hydroxylase in rat brain1Journal of Neurochemistry, 1972
- Regional accumulation of catecholamines formed from tyrosine-14C in rat brain: Effect of chlorpromazineEuropean Journal of Pharmacology, 1969
- Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse BrainActa Pharmacologica et Toxicologica, 1963