Aluminum Intoxication

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Abstract
With the advent of long-term hemodialysis therapy it was anticipated that the symptoms of uremia would be modified and new diseases might occur simply as a result of prolonging a modified uremic state by artificial means. The first new disease discovered in patients with uremia undergoing dialysis was a heretofore undescribed neurologic syndrome called dialysis encephalopathy.1 Subsequently, in 1976, the finding of high concentrations of aluminum in the gray matter of the brains of patients dying from this disease led to the suggestion that it resulted from aluminum intoxication.2 Two years later, European investigators first noted the association between dialysis . . .