HLA AND OTHER IMMUNOGENETIC APPROACHES TO STUDY OF DISEASES IN MAN

  • 1 January 1977
    • journal article
    • editorial
    • Vol. 26  (1) , 5-8
Abstract
Several areas can be practically explored to elucidate the mechanisms accounting for the polymorphism of the human major histocompatibility complex and attendent disease predispositions. In addition to widespread serologic HLA typing of specific populations, diseases and families, it is important to improve discriminating methods for exploration of other areas of the HLA supergene, especially those involved in specific immune responsiveness. Possible modulating effects of the murine histocompatibility complex on other recognized human genes may be a pertinent factor. Application of these improved methods to the study of infertile couples, recognized genetic syndromes and human malignancies may assist in unraveling the immunogenetic enigma of these diseases.

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