Neighbouring hydroxy-group participation in the opening of epoxides by nucleophiles
- 1 January 1973
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 21,p. 839-840
- https://doi.org/10.1039/c39730000839
Abstract
4α,5α-Epoxycholestane and some of its derivatives were prepared and their reactions with sodium azide in refluxing acetone–water were studied; the presence of a 7α-hydroxy-group in the steroidal skeleton accelerates the opening of the epoxy ring by the nucleophile.Keywords
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