Sensitization of Blood Lymphocytes to Possible Antigens in Neurological Disease

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Abstract
Electrophoretic mobility of guinea pig peritoneal macrophages can be used as an indicator to demonstrate the presence in human blood of lymphocytes sensitized to specific antigens. Multiple sclerosis patients show such cells sensitized to encephalitogenic (and usually sciatic nerve) basic protein. Normal subjects do not possess such cells but they occur in other neurological diseases where there is parenchymatous nervous tissue destruction. Possible applications of the method to control of drug therapy is discussed.

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