Studies of acetylcholine- and methacholine-induced sweating

Abstract
Acetylcholine- and methacholine-induced sweating was quantitated over time. Acetylcholine produces sweat more rapidly and more evanescently than methacholine. Methacholine-induced sweating is delayed initially but is prolonged. Amounts of sweat are not always drug-concentration dependent. Sex differences were quantitated. In agreement with previous studies, men consistently produced more sweat than women. Repeated methacholine injections failed to produce a depression in sweating (hidromeiosis). To the contrary, increased amounts of sweat were noted (sweat-gland training).